In one randomized, double-blind 4-week trial, 38 dysthymic men were administered 75mg daily. Itil & Colleagues reported an improvement of symptoms which included anxiety, lack of drive and desire. Next, they administered a high dose (450mg/day) or placebo in a 6-week randomized trial of 52 men with a mean age of 40 years, suffering from dysthymia , unipolar and bipolar depression . Both the mesterolone and placebo groups improved significantly and there were no statistically significant differences between the two groups. In this series of studies mesterolone lead to a significant decrease in LH and testosterone levels. This is probably as a result of the extremely high dose used. In another, 100mg mesterolone cipionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected. 
The leaflets in this section are authored by an experienced pharmacist. Pharmacists are experts in medicines. The medicines in this section include those which act on the endocrine glands. Endocrine glands release hormones (chemicals) into the blood and include the thyroid, pancreas, pituitary, ovaries and testes. Many of the medicines in this section are different types of treatment used in diabetes, but there are also medications for the thyroid (levothyroxine and carbimazole). They include insulin, metformin and gliclazide as well as the newer treatments like sitagliptin and liraglutide. If you've ever thought "Who shouldn't take metformin?", "How do I take my prednisolone?", "How do I get the most from my insulin treatment?" or "What problems can bromocriptine cause?" information leaflets in this section will have answers for you.